DNA methylation is an important modification of DNA, which plays a vital role in regulating gene expression. Coupled with the next generation sequencing technology, DNA methylation analysis in whole genome scale rapidly becomes a powerful technique in the research of gene regulation and disease progression in recent years.

We’re focusing on the bioinformatics analysis of DNA methylation profiling in the whole genome scale. DNA is sequenced by Illumina Genome Analyser following the bisulfite treatment in which all the unmethylated C bases are converted to T bases. The bioinformatics analysis will gather detailed information of whether each C base is methylated and thus provide DNA methylation profiles of different gene regions in the whole genome scale.