- BGI Launches the Latest Desktop Sequencer BGISEQ-50
- International Science Community Welcomes China National GeneBank Opening
- BGI and Clearbridge BioMedics Partner to Develop China CTC Liquid Biopsy Market towards Precision Medicine
- Tadataka Yamada, M.D., Former President of Global Health Program at Bill & Melinda Gates Foundation, Former Chairman of R&D at GlaxoSmithKline, Joins BGI
- The international Sc2.0 Project is on track to build the world’s first synthetic yeast genome
- Avian-specific conserved genomic elements play important regulatory roles in the macroevolution of avian-specific features
- The Evolution of Chronic Lymphocytic Leukemia Revealed
- BGI involved in publication of the first seahorse genome in Nature
- Leading Health Organizations in Canada and China Teaming up to Accelerate Precision Medicine
- World’s largest genomic organisation to collaborate with leading Queensland researchers
- Ranomics Partners with BGI to Classify Variants of Unknown Significance
- BGI and UW collaborate on precision medicine development
- Chinese innovation : BGI’s code for success
- Prof. Huanming Yang to Receive Membership from Royal Danish Academy of Sciences and Letters
- UW, Chinese genomics group forge new partnership to advance biomedical research
- Mapping more genomes will create a healthcare 'big data revolution'
Tel: +86-755-36307212Email: email@example.com
-The Latest Study was Published Online in Nature Genetics-
August 28, 2012, Shenzhen, China – The international research team led by Chinese Academy of Agricultural Sciences and BGI have completed the genome sequence and analysis of a diploid cotton-- Gossypium raimondii. The cotton genome provides an invaluable resource for the study and genetic improvement of cotton quality and output, and sheds new lights on understanding the genetic characteristics and evolutionary mechanism underlying cotton and its close relatives. The study was published online in Nature Genetics. (http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.2371.html).
Cotton, also known as “white gold”, is an important cash crop worldwide. Its fiber is one of the oldest fibers under human cultivation, which traces over 7,000 years old recovered from archaeological sites. The cotton production provides income for approximately 100 million families, and approximately 150 countries are involved in cotton import and export. Additionally, in scientific research, cotton also serves as an excellent model system for studying polyploidization, cell elongation and cell wall biosynthesis.
In this study, researchers sequenced the genome of G. raimondii by the next-generation sequencing technology, yielding a draft cotton genome with 103.6-fold genome coverage. Over 73% of the assembled sequences were anchored on 13 G. raimondii chromosomes. They identified 2,355 syntenic blocks in the G. raimondii genome, and found that approximately 40% of the paralogous genes were present in more than 1 block, which suggests that this cotton genome has undergone substantial chromosome rearrangement during its evolution.
Through comprehensive comparison and analysis, researchers observed that one paleohexaploidization event occurred in the G. raimondii genome at approximately 130.8 million years ago, while the event is commonly found in eudicots. They also found the evidence to support a cotton–specific whole–genome duplication event occurred at approximately 13-20million years ago.
Cotton is known to produce a unique group of terpenoids such as gossypol. The accumulated gossypol and related sesquiterpenoids produced by cotton in pigment glands can be as a resistance against pathogens and herbivores. The majority of cotton sesquiterpenoids are derived from a common precursor which is synthesized by (+)- δ -cadinene synthase (CDN) in gossypol biosynthesis. Through the phylogenetic analysis on G. raimondii and eight other sequenced plant genomes, they found that the cotton, and probably Theobroma cacao, were the only sequenced plant species that possess an authentic CDN1 gene family for gossypol biosynthesis.
Furthermore, the transcriptomic comparison between the fiber-bearing G. hirsutum and the non-fibered G. raimondii demonstrated that three synthases are important for cotton fiber development, including sucrose synthase (Sus), 3-ketoacyl-CoA synthase (KCS) and 1-aminocyclopropane-1-carboxylic acid oxidase (ACO). Meanwhile, the MYB and bHLH transcription factors preferentially expressed in fiber may be useful to explain the molecular mechanisms that are in charge of governing fiber initiation and early cell growth.
Zhiwen Wang, Project Manager at BGI, said, “The completed G.raimondii genome provides a good reference for accelerating the genomic research on tetraploid cotton species such as G. hirsutum and G. barbadense. It also will lay a solid foundation for researchers to further boost cotton quality and productivity by comprehensively exploring the genetic mechanisms underlying cotton fiber initiation, gossypol biosynthesis and resistance against pathogens and herbivores.”
Public Communication Officer