- BioNano Genomics Announced the Purchase of IrysTM System by BGI
- QIAGEN partners with BGI Tech to provide services based on the Human Gene Mutation Database (HGMD) in Greater China
- BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics’Advanced Platform
- BGI announces first flagship project with the Edinburgh Genome Foundry to synthesize the largest synthetic eukaryotic chromosome in the UK
- BGI Reports a Novel Gene for Salt Tolerance Found in Wild Soybean
- Researchers Develop a New Genome Editing Method, Bringing the Possibility of Patient-specific Gene Therapies Closer to Reality
- BGI Presents a High-quality Gene Catalog of Human Gut Microbiome, A Key to Understanding Human Health and Diseases
- BGI Reports the Evolutionary Adaptations of Tibetans May Benefited from Extinct Denisovans
- BGI Health Forms Partnership with University of Mayor in South America
- BGI Health and Sir Ganga Ram Hospital Collaborated to Introduce NIFTY Test to India
- BGI Health Joins Hand with Star Metropolis Clinical Laboratories to Provide Genetic Testing Service
- BGI-Hong Kong 3730 Production Center Begins Operating, Providing Fast and High-quality Sequencing Services
- China's genomics success shows big data challenges
- Joe Biden is wrong. China does innovate
- Mainland scientific research company BGI expands its Hong Kong operations
- BGI Plans to Sequence the World
Tel: +86-755-25031760Email: firstname.lastname@example.org
-The latest research was published online in Nature Genetics
Shenzhen, June 15, 2014---An international team, composed of 11 institutions from six countries, including BGI, presented the whole-genome sequence of Trichuris suis, a parasitic worm in pig. Understanding the genetics mechanisms underlying the pig parasite may aid to modify the human immune response that could result in better treatments for autoimmune diseases, including inflammatory bowel disease (IBD) and multiple sclerosis. The latest research was published online in Nature Genetics (http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3012.html#affil-auth).
The human whipworm (Trichuris) infects around 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic loses. In contrast, the pig whipworm causes disease and losses in livestock, but it does not cause disease in humans. It’s reported that pig whipworm infection could even prevent inflammatory disease in humans, and has been used to treat inflammatory bowel disease and multiple sclerosis.
In this study, researchers sequenced the genomes of single adult female and male pig whipworm at about 140-fold coverage, producing draft assemblies of 76 Mb and 81 Mb, respectively. It was previously reported that the XX and XY karyotypes for female and male whipworm, respectively, but in this study researchers found no evidence for a Y chromosome among the male-specific scaffolds, suggesting that the sex chromosomes were the smallest chromosomal pair and were morphologically very similar in both sexes.
Intriguingly, they found the microRNAs (miRNAs) seem to have a major role in regulating sexual development in this species. Among them, the tsu-miR-228 in male, and tsu-miR-236 and tsu-miR-252 in female worms were predicted to regulate and suppress key feminizing and masculinizing developmental genes, respectively. According to the authors, this is the first time they observed such results in a metazoan.
When investigating how pig whipworm regulates the host immune response, researchers explored the stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs. The secretory proteins showed high representation in transcriptome of pig whipworm. The peptidases, particularly the secreted peptidases upregulated during larval development and in the stichosome, seemed to have a central role in human autoimmune disorders, primarily through inhibiting inflammation. Researchers also constructed the models of inflammatory bowel disease and other autoimmune disorders, trying to figure out a way for parasite-derived therapies.
Li Hu, Project Manager from BGI, said, “The constructed pig whipworm genome sequence provides us a genetic resource for deeply investigating the mechanisms underlying human autoimmune diseases. Meanwhile, the pig whipworm-host interactions will shed new light on the control of helminth and other immunopathological diseases in human. ”
Bicheng Yang, Ph.D.
Public Communication Officer