BGI-Shenzhen, the world's largest genomics research center, currently has  Illumina/Hiseq2000 Illumina/hiseq 2500Illumina/Miseq Life Tech/ SOLiD4Life Tech/Ion protonLife Tech/Ion torrent PGMRoche/454 GS FLX and ABI/3730xl sequencing platforms, selecting different sequencing platform according to different needs of research and application. The ongoing applied research are as following: DNA sequencing, Small RNA sequencing, transcriptome sequencing, digital expression profiling sequencing, ChIP-Seq, DNA methylation, the target area to capture sequencing, metagenomic sequencing and so on. These technical systems serve research, practice and service application as a whole and cover various key research areas.

New Technology Division of BGI Research

DNA sequencing technology is the basis for biological research. The development of High-throughput, high-precision sequencing technology has important strategic significance in the life sciences, biomedical and clinical medical fields. Nowadays, there are many types of sequencing machines, have their own characteristics and advantages. BGI is committed to build different sequencing platforms to meet diverse applications. The equipment and technologies are needed for the large-scale genomic research center. Current work: 1) Ion Proton platform, the representative of the bench top next-generation sequencer, using a unique ion semiconductor chip technology. It only takes a few hours to provide the sequence data of the whole human genome, the exome or the entire transcriptome. Faster and more flexible than other sequencers. The read length is 100-200bp, and the accuracy is consistent with the Ion PGM sequencer; 2) CG platform, Complete Genomics proprietary whole human genome sequencing technology (the DNA Nano-ball Arrays), provides high-quality data (99.9998% accurate). And the throughput of a single machine is more than 10 times of competitors which in the same type. Two platforms bring the technologies to application effectively.

In addition to the powerful hardware platform, there are many soft technology platforms.  

Breeding experimental technology research and development platform

For the molecular breeding process of animals and plants, using experimental techniques for development as well as improvement, for example in genome-wide selection process involves large-scale rapid DNA extraction, quick access to marker genotypes and other related operations, and at present these technologies can’t meet massive demand, so DNA extraction techniques and Genotyping system need further research and development.

Functional verification research and development platform

In association analysis experiment, a large number of association signal could be identified, which requires an efficient verification system for functional verification, and the explanation of molecular mechanisms.

Breeding relevant statistical model research and development platform

Molecular breeding process involves a variety of statistical models, the genotype phenotype correlation to individual breeding value prediction, breeding efficiency of breeding populations for a plurality of different situations during the establishment of the corresponding statistical model to be and accurately guidance only breeding.

Breeding database established Platform

Using some of the above techniques, combine the network, and the programming knowledge to build a practical breeding database.

Cancer individualized treatment technology research and development platform

Individualized treatment of cancer patients with cancer drugs based on genetic and pharmacogenomic characteristics, the specific chemotherapy drug regimens and optimal chemotherapy approach, which can help patients choose the right chemotherapy drugs, improve the treatment of targeted cancers, provide the greatest degree of prolong the survival of patients. Development of tumor targeting agents includes predicted molecular screening monitor individual tumor markers with clinical urine DNA detection technology, in order to detect mutations in clinical patients and post-treatment monitoring.

The low frequency of tumor detection technology research and development platform

Including those based on the early diagnosis of colon cancer feces, urine bladder cancer early diagnosis, circulating tumor cells and cell-free DNA sequencing technology development. The low frequency of tumor detection technology development achieves new breakthroughs in cancer genomics research and builds a new technology platform in cancer research.

Microfluidic technology research and development platform

Include microfluidic chip design, processing and manufacturing. Primarily for single-cell capture, nucleic acid extraction, nucleic acids and other carriers to provide the most advanced support. Also it will be included on chip PCR, Point of Care systems and other development projects.

Symbiotic microorganisms and human health research platform

Symbiotic microbes in the human body for the study, and the study of human symbiotic microbes microbial symbiosis between health and human relations. In the next 1-3 hours, plans to build human commensal microbiology laboratory BGI relying on a large variety of platforms through genomics laboratory. Combined production of microbial sequencing, information analysis, microbiological screening, and microbial functional verification, progressive research and reveal the human gut microbes and disease relationships, human gut microbes and the relationship between diet, has the human gut microbes and host metabolism, genotype between.

Proteomics research Platform

The research interests include protein identification, quantification, modification, and interaction at all levels of proteomics research. Currently mainly for proteomics core software and algorithms related to the development and the associated development of experimental techniques and applications.

Metabolomics research platform

It is the newly developed discipline, through the relative molecular mass 1000Da vivo small-molecule metabolites within the qualitative and quantitative analysis, looking for metabolites with physiological and pathological changes in the relationship. Aims to conduct individualized metabolomics analysis for nutritional status, health, disease diagnosis and treatment.