Combined with hand-made cloning and whole genome  molecular breeding technology, BGI has established a platform for boar-selection, in which some domestic breeds of high-quality are housed, including Bama mini-pigs and Tibetan mini-pigs. Totally, there is a well-equipped pig farm over 200 mu and 160 square meters of ultra-clean SPF mouse rooms. Till now, animal models of dwarfish, type 2 diabetes mellitus have been developed via genetic engineering. In the future, more models, such as cardiovascular, cancer, neurodegenerative diseases, will be generated.



Experimental base 
Mouse House

Development of disease model

Applying genetic engineering techniques,such as transgenesis, RNAi and Knock-out, we have developed several new humanized animal models for cancer (Breast cancer, nasopharyngeal carcinoma ), diabetes, and cardiovascular disease, using mouse, rat and minipig. We have also developed several new animal models for Mendelian disease, based on new findings of unlocking Mendelian disease using exome sequencing.

Development of genetically modified min-pet

By means of genetic manipulation of growth-aix related genes, we have developed several new min-pet lines for pig, goat and rabbit, featured by small, slow-growing, and genetic stability. These mini products will be used as mini pet, and also as a dwarfism model for human biomedicine research.  

Gene-Knockout Plan in Mammals

Applying optimized the TALEN and CRISPR systems, we have completely knocked out more than 20 genes in mammals, such as mouse ACE2, TXNIP, Caspase-1, HAS3, BRCA1 and pig GHR, GHRHR, HMGA2, P53. Strikingly, the knockout efficiency achieves 50%, 20% of which are biallelic deletions. Currently, we can prepare modified cell lines and mice in 4 months, which saves time for disease model manufacturing.