Development of disease model
Applying genetic engineering techniques,such as transgenesis, RNAi and Knock-out, we have developed several new humanized animal models for cancer (Breast cancer, nasopharyngeal carcinoma ), diabetes, and cardiovascular disease, using mouse, rat and minipig. We have also developed several new animal models for Mendelian disease, based on new findings of unlocking Mendelian disease using exome sequencing.
Development of genetically modified min-pet
By means of genetic manipulation of growth-aix related genes, we have developed several new min-pet lines for pig, goat and rabbit, featured by small, slow-growing, and genetic stability. These mini products will be used as mini pet, and also as a dwarfism model for human biomedicine research.
Gene-Knockout Plan in Mammals
Applying optimized the TALEN and CRISPR systems, we have completely knocked out more than 20 genes in mammals, such as mouse ACE2, TXNIP, Caspase-1, HAS3, BRCA1 and pig GHR, GHRHR, HMGA2, P53. Strikingly, the knockout efficiency achieves 50%, 20% of which are biallelic deletions. Currently, we can prepare modified cell lines and mice in 4 months, which saves time for disease model manufacturing.
- [news]Collaboration for Large-scale Genome Sequencing of Cassava – Fourth Major Food Crop in Developing World – Announced by BGI and International Center for Tropical Agriculture
- [news]BGI Unveils Significant New Global Research Collaborations at The 6th International Conference on Genomics
- [news]BGI Enters Collaborative Agreement with Lal Teer Livestock Limited Targeting Water Buffalo Genome Project
- [news]BGI and the Bill & Melinda Gates Foundation Sign Memorandum of Understanding on Collaboration for Global Health and Agricultural Development
- [news]Rising in the East
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