On April 14, 2003, Presidents of six countries jointly announced the success of Human Genome Sequencing.

In April, 2003, BGI spontaneously started the anti-SARS research by carrying out a series of systematic research on whole genome shotgun sequencing, protein analysis, diagnostic reagent kit, drug screening.

In the year of 2003, BGI was the first institute that decoded the whole genome sequence of four kinds of SARS viruses, and developed the diagnostic antigen, antibody and related tags At the same time, ELISA Kit, the first diagnostic reagent of SARS in the world, was produced by BGI.

On April 20, 2003, Chairman of PRC, Mr Hu Jintao, accompanied by President of CAS, Mr Lu Yongxiang and Vice-President Mr Chen Zhu, visited BGI and paid their high tributes to all the scientists and researchers who had devoted greatly in the fight against SARS Mr Hu Jintao encouraged the scientists and researchers to continue their concerted and unyielding efforts with confidence, carry forward patriotic spirits in the scientific researches in order to serve the people better by protecting them from diseases and harm He spoke highly of the scientists who were always bearing the urgent need of the center government and people in mind.

On June 1, 2003, BGI collaborated with Southwest University in the project of national domestic silkworm genome project The working frame map of domestic silkworm genome was completed on September 18, 2003.

On November 28, 2003, BGI, CAS was approved by the Central Government.