In January, 2010, BGI has purchased 128 HiSeq 2000 sequencing systems, representing the largest single order for next-generation sequencing systems to date

On January 9, 2010, BGI officially launched the 1000 plant and animal reference genome project and calls for the collaboration from all over the world

In January, 2010, The article entitled, “Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx)”, “The genome of the cucumber, Cucumis sativus L” , “The sequence and de novo assembly of the giant panda genome” have recently been featured on Nature China, an online publication from Nature Publishing Group, the publisher of Nature

On February 10, 2010, BGI and University of Copenhagen reported online in Nature that they have sequenced an ancient human genome using DNA isolated from preserved hair samples found in Greenland’s permafrost

On March 3, 2010BGI led research team published a proof-of-principle metagenomics study using short read sequencing to catalog and characterize the microbial genes present in the human gut

Next Generation Sequencing Platform of BGI-Shenzhen has received the ISO9001 certification issued by SGS on March 18th, 2010

On March 19th, 2010, BGI and US teams announced “the symbiont genome project”, which is to sequence the genomes of sea slug, Elysia chlorotica and its algal food Vaucheria litorea

On April 13th, 2010, The Chinese Marrow Donor Program (CMDP) officials led by the Director of Volunteer Database Management Center, Liu Jinghu, surveyed oral mucosa swab sampling activity which was carried out in BGI

On April 27th, 2010, BGI Americas was founded and set up the head office in Boston, US

On May 3rd, 2010, the single base-resolution methylome of the silkworm, accomplished by the joint efforts of BGI, Kunming Institute of Zoology, Shanghai Cancer Institute, and Southwest University, was published online by Nature Biotechnology

On May 13th and 14th, 2010, the International Conference on the Progress of “1000 Plant and Animal Reference Genomes Project” ("1000 Project" for short) was held in BGI-Shenzhen, China

On May 17th 2010, 15:00 Denmark local time, the set up of BGI Europe in Copenhagen, Denmark was officially announced

On May, 22nd, 2010, the President of BGI, Mr Wang Jian, Dr Chen Fang, together with the Chairman of China Vanke, Mr Wang Shi and other mountaineers, have successfully ascended the summit of Mount Everest, the most inaccessible place in the world

On June 9, 2010, a collaborative research team from King Abdulaziz City for Science and Technology (KACST), Saudi Arabia and BGI, is the first in the world to successfully map the full genome of Arabian camel (Camelus dromedarius)

On June 28, 2010, the Symposium on Rice Genomics and Agricultural Application initiated by BGI was successfully held in Shenzhen

On July 2, 2010, initiated and finished by the leading of BGI-Shenzhen, Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude was published on Science

On July 21, 2010, primarily undertaken by BGI-Shenzhen, A human gut microbial gene catalogue established by metagenomic sequencing was selected as Research Highlights by Nature China

From July 29 to 30, 2010 Symposium on Human Pathogen Genomics, jointly hosted by Professional Committee of Analytical Microbiology of Chinese Society for Microbiology, Institute of Microbiology of Chinese Academy of Sciences and BGI-Shenzhen, was held in Shenzhen

On July 31, 2010, whole genome sequence map of oyster was jointly completed by Institute of Oceanology of Chinese Academy of Sciences, State University of New Jersey and BGI-Shenzhen

On July 31 2010, Yellow Sea Fisheries Research Institute (YSFRI) Chinese Academy of Fishery Sciences and BGI-Shenzhen, jointly announced the complete sequencing and assembly of Cynoglossus semilaevis genome

On August 4, 2010, initiated and finished by the leading of BGI-Shenzhen, Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude published on Science was selected as Research Highlights by Nature China

On August 8, 2010, the Seminar on Leukemia and Genome Research among Chinese Natural Population undertaken by BGI-Shenzhen was held in Shenzhen

An international team of researchers at Arizona State University, BGI-Shenzhen, New York University School of Medicine, and University of Pennsylvania School of Medicine, reported on 27th August in Science the genomes of two ant species: Camponotusfloridanus and Harpegnathossaltator

From Sept2 to Sept4, 2010 International Ophthalmic Disease Genetics Research Conference, hosted by BGI-Shenzhen and University of California, San Diego, USA, was held in Shenzhen

On September 6, 2010, Epitwin, one of the most ambitious large-scale epigenetics projects, was launched by TwinsUK and BGI-Shenzhen

On September 10, 2010, BGI-Shenzhen and Beijing Obstetrics and Gynecology Hospital signed agreements of sino-danish clinical genetics cooperation and non-invasive prenatal genetic screening project

On September 11, 2010, the signing ceremony of joint PhD program between BGI-Shenzhen and University of Copenhagen was held in Shenzhen

On September 15, 2010, Merck and BGI signed statement of intent to collaborate to advance the application of genomics in medicine

Amsterdam, Netherlands, 23rd September 2010 “The Netherlands Genome Project”, a collaboration between the Netherlands Genome Consortium and BGI, was announced

On September 23, 2010, the signing ceremony of joint PhD program between BGI and Aarhus University was held in Shenzhen

On October 4, 2010, an international research group reported the resequencing and analysis of 200 human exomes, established the largest data set for human exomes published so far and reveal an excess of low frequency deleterious non-synonymous genetic mutations

On October 25, Nature Genetics published online a whole genome map of single nucleotide polymorphism, insertion/deletion variation and the gene content variation among elite maize lines in China by an international team including scientists from China Agricultural University, BGI, Iowa State University, University of Minnesota and University of Copenhagen

International Ancient Genomic Research Symposium, co-organized by BGI-Shenzhen and University of Copenhagen was held from 26th to 27th Oct, 2010 in Shenzhen, China

On October 28 London Time, Nature published analysis of completed pilot phase of The 1000 Genomes Project

On October 28, 2010, BGI-Shenzhen and its affiliate BGI Hong Kong Co, Limited announced today that it has successfully completed Illumina CSPro™ certification for Sequencing

On October 29, 2010, Life Technologies Corporation and BGI announced today that it has partnered with BGI to offer whole human genome resequencing on the SOLiD™ 4 System

On 4th November, 2010, BGI, the largest genomics organization in the world, and OpGen, the exclusive provider of Optical Mapping Technology, announced their joint-effort to expand the use of Optical Mapping for de novo sequence finishing in human, plant and animal genomes

BGI researchers decoded the essentially complete methylome (an inventory of all the bases that are methylated) of the human genome using peripheral blood mononuclear cells (PBMCs) The results was published in PLoS Biology on November 9

On November 13, the annual meeting of Sino-Danish Cancer Research Center was held in BGI-Shenzhen and 16 scientists from University of Copenhagen, Aarhus University and University of Southern Denmark attended

A research team composed of scientists from the Chinese University of Hong Kong, BGI-Shenzhen, the Chinese Ministry of Agriculture, the Chinese Academy of Agricultural Sciences and University of Copenhagen, reported a large-scale analysis of the patterns of genome-wide genetic variation in soybeans The results were published online in Nature Genetics on 14th November 2010

On November 15, 2010, the Signing Ceremony of Thalassemia Salvation Project between BGI and Red Cross of Shenzhen Branch, and the press release of BGI and ZhangJiaKou Academy of Agricultural Sciences signing strategic cooperation framework agreement of Foxtail Millet were held in Shenzhen Convention and Exhibition Center

The 5th International Conference on Genomics (ICG-V), co-organized by Beijing Genomics Institute (BGI-Shenzhen), University of Delaware, University of California San Diego, Boyce Thompson Institute of Plant Research, Cornell University, Institute of Oceanography and Chinese Academy of Sciences, was held from 16th to 18th Nov, 2010 in Shenzhen, PR China

On November 18,2010, the press conference of introducing (Giga) n Science was held at the end of the 5th International Conference on Genomics (ICG-V)

On November 23, 2010, the journal article of “TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing” was published in the online journal of neurology and this correspondence to BGI, Central South University and other institutions

On November 29, 2010, the first litter of “man-made cloned pigs which produce omega-3 fatty acids” were born and this project was carried out by BGI and the Institute of Genetics and Developmental Biology, CAS

On November 30, 2010, BGI and The Genome 10K Consortium of Scientists (G10KCOS) together announced to start the first phase of the Genome 10K Project

On December 3, 2010, the “2010 Medical Science Frontier Forum – The Development Direction and the Current Research of Human Genome and the Growth - Immune – Cancer Seminar” was held in Shenzhen, and this was co-organized by BGI and the Institute of Medical Information, CAS

On December 17, 2010, Science published ten science breakthroughs of 2010, including Quantum Machine, Build Your Own Genome, Reading the Neandertal Genome, Next-Generation Genomics, Souped-up cellular Reprogramming, Homing In on Errant Genes, Quantum Simulators Pass First Key Test, Molecular Dynamics Simulations, Rats Redux and HIV Prophylaxis In the “Next-Generation Genomics”, “Ancient human genome sequence of an extinct Palaeo-Eskimo” and “A map of human genome variation from population-scale sequencing”, which were BGI’s two cooperative research findings, were cited as references

On December 17, 2010, “The Year In News” which was published in Science had reviewed 37 items of developments that tested the limits of knowledge and influenced thinking about the global research enterprise BGI-Shenzhen was chosen as one of the news: “Ongoing: BGI-Shenzhen enhances its reputation as world’s largest sequencing center, deciphering an ant, a paleo-Eskimo, the human methylome, and a gene catalog of the human gut microbiome”

On December 17, 2010, Science published ten “Insights of the Decade”, and those which were under the biological science field include The Dark Genome, Ancient DNA, Reprogramming Cells, The Microbiome and inflammation“The Dark Genome” has pointed out that BGI’s participation has significant importance in the completion of the “International Human Genome Project” In addition, “The Microbiome” had emphasized BGI’s contribution as the primary publisher of the journal article “A human gut microbial gene catalogue established by metagenomic sequencing” and its significance in pioneering research

On December 17, 2010, the Signing Ceremony of the Asparagus Genome International Coperation Project between BGI and Jiangxi Academy of Agricultural Sciences was held in Nanchang, China.