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New Features Discovered on Lipid Metabolism in T2D in Chinese Patients in Association with BGI

July 15, 2017
华大联合多家单位发布“药用植物4.0计划”,并与广西药用植物园签订战略合作协议

BGI Research, CNGB and Suzhou Disease Control Center jointly concluded their first research project concerning non-targeted plasma lipidomics for the Chinese population. The research is the first to uncover the composition and differences in plasma lipid metabolism among type two diabetics (T2D), pre-diabetics, and people with normal amounts of glucose, which embarks on further research studying lipid metabolism in the Asian subpopulation. This latest research is published and available on Giga Science.

This research is the first large-scale non-targeted study looking at lipid metabolites in Chinese patients. The aim of this study was to examine Asian T plasm lipid metabolites characteristic at different stages of diabetes. Zhong Huanzi, a major researcher of the project, said, “Apart from very few lipids, most lipid differences have never been reported before. Thus, we display a full and clear picture of lipid metabolism in Chinese T2D patients. Moreover, most lipids have strong correlations with T2D symptoms, such as fasting blood glucose, after-meal blood glucose, insulin resistance index; this opens up the possibility of determining the role of lipids in diabetes.” Li Junhua, another major researcher, considered the project as an excellent opportunity for further research and explained that “data and technologies from this project are sound and helpful for large-scale research on the lipid metabolic network in T2D and other metabolic diseases. This project guides us to prevent, diagnose and treat these diseases at a new level.”

Further reading
Huanzi Zhong, Chao Fang, Yanqun Fan, et al. Lipidomic profilingreveals distinct differences in plasma lipid composition in healthy,prediabetic, and type 2 diabetic individuals. Gigascience2017; 6 (7):1-12. doi: 10.1093/gigascience/gix036